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epigenetics 3

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histone modifications 2

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autoimmune-related skin diseases 1

chicken 1

climacteric fruit ripening 1

climacteric fruit ripening / phytohormones / TFs / epigenetic modifications 1

dysplasia 1

enhancer of zeste homolog 2 (EZH2) 1

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETICMODIFICATIONS

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also playevaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigeneticmodifications during climacteric fruit ripening.

Keywords： climacteric fruit ripening / phytohormones / TFs / epigenetic modifications    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETICMODIFICATIONS

Yinglin JI, Mingyang XU, Aide WANG

Frontiers of Agricultural Science and Engineering   Pages 314-334 doi: 10.15302/J-FASE-2021386

Abstract: Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also playevaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigeneticmodifications during climacteric fruit ripening.

Keywords： climacteric fruit ripening     phytohormones     TFs     epigenetic modifications    

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Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 231-241 doi: 10.1007/s11684-013-0253-7

Abstract:

Hepatocellular carcinoma (HCC) development is characterized by the presence of epigenetic alterations, including promoter DNA hypermethylation and post-translational modifications of histone, which profoundlyIn this review, we will first recapitulate the mechanisms of two key epigenetic pathways: DNA methylationand histone modifications.our understanding on the roles of PcG proteins in hepatocarcinogenesis can benefit the development of epigenetic-based

Keywords： liver cancer     epigenetics     histone modifications     polycomb group proteins     enhancer of zeste homolog 2 (EZH2    

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The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 378-384 doi: 10.1007/s11684-010-0230-3

Abstract: Developing esophageal cancer is a multi-step process that begins with the accumulation of genetic and epigeneticIn addition to genetic alteration, epigenetic modifications, and in particular DNA methylation, are recognizedThis review is mainly focused on epigenetic changes in esophageal cancer and the value of early detection

Keywords： epigenetics     DNA methylation     esophageal cancer     dysplasia    

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environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 176-184 doi: 10.1007/s11684-021-0885-y

Abstract: Studies of human and mammalian have revealed that environmental exposure can affect paternal health conditions as well as those of the offspring. However, studies that explore the mechanisms that meditate this transmission are rare. Recently, small noncoding RNAs (sncRNAs) in sperm have seemed crucial to this transmission due to their alteration in sperm in response to environmental exposure, and the methodology of microinjection of isolated total RNA or sncRNAs or synthetically identified sncRNAs gradually lifted the veil of sncRNA regulation during intergenerational inheritance along the male line. Hence, by reviewing relevant literature, this study intends to answer the following research concepts: (1) paternal environmental factors that can be passed on to offspring and are attributed to spermatozoal sncRNAs, (2) potential role of paternal spermatozoal sncRNAs during the intergenerational inheritance process, and (3) the potential mechanism by which spermatozoal sncRNAs meditate intergenerational inheritance. In summary, increased attention highlights the hidden wonder of spermatozoal sncRNAs during intergenerational inheritance. Therefore, in the future, more studies should focus on the origin of RNA alteration, the target of RNA regulation, and how sncRNA regulation during embryonic development can be sustained even in adult offspring.

Keywords： small noncoding RNAs     epigenetic inheritance     paternal intergenerational inherence     extracellular vesicles    

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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: combating viral infection, the intercellular transfer of pathogen and host-derived materials and their epigenetic

Keywords： innate immune     viral infection     intercellular signaling     metabolic changes     epigenetic changes    

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The critical importance of epigenetics in autoimmune-related skin diseases

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 43-57 doi: 10.1007/s11684-022-0980-8

Abstract: pathogenesis of these disorders are poorly understood, environmental variables that induce aberrant epigeneticThe most important epigenetic mechanisms are DNA methylation, histone modification, and noncoding RNAsIn this review, we discuss the most recent findings regarding the function of epigenetic mechanisms in

Keywords： epigenetics     autoimmune-related skin diseases     DNA methylation     histone modifications     noncoding RNAs    

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The genetic regulation of skeletal muscle development: insights from chicken studies

Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 295-304 doi: 10.15302/J-FASE-2017159

Abstract: involved in the regulation of skeletal muscle development in the chicken, such as gene polymorphisms, epigenetic

Keywords： chicken     epigenetic modification     miRNAs     skeletal muscle development     SNP     transcription factor    

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Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications Article

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Engineering 2021, Volume 7, Issue 10,   Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014

Abstract:

The coronavirus disease 2019 (COVID-19) pandemic has led to worldwide efforts to understand the biological traits of the newly identified human coronavirus (HCoV-19) virus. In this mass spectrometry (MS)-based study, we reveal that out of 21 possible glycosites in the HCoV-19 spike protein (S protein), 20 are completely occupied by N-glycans, predominantly of the oligomannose type. All seven glycosylation sites in human angiotensin I converting enzyme 2 (hACE2) were found to be completely occupied, mainly by complex N-glycans. However, glycosylation did not directly contribute to the binding affinity between HCoV-19 S protein and hACE2. Additional post-translational modification (PTM) was identified, including multiple methylated sites in both proteins and multiple sites with hydroxylproline in hACE2. Refined structural models of HCoV-19 S protein and hACE2 were built by adding N-glycan and PTMs to recently published cryogenic electron microscopy structures. The PTM and glycan maps of HCoV-19 S protein and hACE2 provide additional structural details for studying the mechanisms underlying host attachment and the immune response of HCoV-19, as well as knowledge for developing desperately needed remedies and vaccines.

Keywords： N-glycosylation     COVID-19     Spike protein     hACE2     Structure    

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Title Author Date Type Operation

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETICMODIFICATIONS

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETICMODIFICATIONS

Yinglin JI, Mingyang XU, Aide WANG

Journal Article

Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Journal Article

The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Journal Article

environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic

Journal Article

Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Journal Article

The critical importance of epigenetics in autoimmune-related skin diseases

Journal Article

The genetic regulation of skeletal muscle development: insights from chicken studies

Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG

Journal Article

Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Journal Article